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KMID : 0350519960490030995
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Journal of Catholic Medical College
1996 Volume.49 No. 3 p.995 ~ p.1006
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Effect of Basic-Fibroblast Growth Factor on Xenograft Rat
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Abstract
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The purpose this study was to assess the effect basic-fibroblast growth factor (bFGF) on the xenograft for radial bone defect in adult rats. Twenty adult Wistar rats weighing between 200 and 250 g were divided into two groups; bFGF group (10
rats,
20
radiuses) and non-bFGF group (10 rats, 20 radiuses). A segmental bone defect measuring 5 ㎜in length was made at both radiuses 10㎜proximal to the wrist joint. The defect was filled with xenograft (Lubboc(r)) measuring 3×3×5㎜in size. The
xenograft
was treated with 400 ng/㎖bFGF (recombinant human basic-fibroblast growth factor) mixed with liquid collagen (Vitrogen 100(r)) in the bFGF group, but with collagen alone in the non-bFGF group.
@ES The results were as follows;
@EN 1. The new bone formation and maturation from the differentiation of osteoblast was more remarkable in the bFGF than in the non-bFGF group.
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KEYWORD
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